|Voiced by||Tress MacNeille|
Cuddlesworth (friend, possible boyfriend)
|First Appearance||The Prince and the Pupper|
|Additional Appearances||The Ruff Ruff Bunch|
In "The Ruff Ruff Bunch," Pickypuss came to the Pound Puppies for help finding Cuddlesworth, who had mysteriously disappeared. They soon found Cuddlesworth running a gang of street dogs. Pickypuss learned that Cuddlesworth had left after she'd complimented him by calling him a "pussycat," unaware that a dog would consider such a word to be an insult. She and Cuddlesworth reconciled, and they, along with the Super Secret Pup Club, went to the spa.
- It is heavily implied that Pickypuss and Cuddlesworth are in a romantic relationship, especially in "The Ruff Ruff Bunch," where they call each other names like "darling" and "beloved."